Best Baby Formula for Constipation: Our Top 10 Picks & Reviews

Introduction

Watching your little one struggle with constipation can be heartbreaking for any parent. Finding the right nutrition is key to their comfort and your peace of mind. After rigorous testing and evaluation, we’ve determined that the best solution for most families is the Enfamil NeuroPro Gentlease Fussiness Relief Baby Formula. Its specialized formula, featuring partially hydrolyzed proteins that are easier for tiny tummies to break down, and a patented PDX & GOS prebiotic blend, works effectively to support softer stools. This combination directly addresses the core issues behind formula-related constipation, providing gentle and rapid relief.

Our Top 10 Picks for Best Baby Formula for Constipation

#1 Enfamil NeuroPro Gentlease Fussiness Relief Baby Formula – Ideal for: Rapid Relief from Gas and Constipation

When dealing with a fussy, constipated baby, you want a solution that works quickly and gently, and in our testing, the Enfamil NeuroPro Gentlease Fussiness Relief Baby Formula delivered on all fronts. What stood out to us immediately was its formulation. It uses partially hydrolyzed proteins, which are essentially smaller, pre-digested proteins that are much easier for a baby’s developing digestive system to handle. This single feature is a game-changer for infants struggling with gas and hard stools. We noticed a visible difference in comfort levels within the first day of switching, a sentiment echoed by countless users who reported reduced crying and fussiness in under 24 hours. The inclusion of a PDX & GOS prebiotic blend is another key factor in its effectiveness. This blend is specifically designed to nourish beneficial gut bacteria, which in turn helps promote softer, more regular bowel movements, closely mimicking the digestive benefits of breast milk. We also value the addition of brain-building nutrients like DHA and MFGM, ensuring that while we’re solving tummy troubles, we’re not compromising on crucial cognitive development. The powder mixed smoothly without clumping, which is always a plus during late-night feedings.

#2 Enfamil NeuroPro Baby Formula with DHA & HU50 – Perfect for: Overall Brain and Immune Development

While not specifically marketed for constipation, we found the Enfamil NeuroPro Baby Formula with DHA & HU50 to be an excellent, well-tolerated option for many babies who don’t have severe digestive issues but could still benefit from a gentle formula. Its main strength lies in its comprehensive nutritional profile, designed to mimic breast milk closely. It features MFGM (Milk Fat Globule Membrane), a component clinically shown to support cognitive development, alongside expert-recommended levels of DHA. In our experience, babies transitioned to this formula smoothly, and it was gentle on their stomachs. The powder dissolved easily, creating a smooth consistency that was well-received. Many users confirmed our findings, noting that their babies had no issues with upset stomachs or gas on this formula. The exclusive HuMO6 immune blend is another standout feature, providing peace of mind that you’re supporting your baby’s immune system. While it lacks the specialized partially hydrolyzed proteins of the Gentlease version, its easy-to-digest protein base is still suitable for many infants. For parents looking for a premium, brain-boosting formula that is also gentle, this is a top-tier choice.

#3 Similac 360 Total Care Infant Formula 5 HMO Prebiotics – Suits: Parents Needing On-the-Go Convenience

For parents who prioritize convenience without sacrificing nutrition, the Similac 360 Total Care Infant Formula 5 HMO Prebiotics is an unbeatable option. These ready-to-feed 2-ounce bottles were a lifesaver for us during travel and late-night feedings. There’s no measuring, mixing, or warming required—just attach a nipple and it’s ready. This convenience is a huge stress-reducer. Nutritionally, this formula is a powerhouse. It features an exclusive blend of five different HMO prebiotics, which is the brand’s closest formulation to the prebiotics found in breast milk. This prebiotic blend is fantastic for digestive health, helping to cultivate a healthy gut microbiome and, in turn, promoting softer stools and reducing the likelihood of constipation. We found that babies who were previously on the powder version of this formula took to these bottles without any issues, and their digestive regularity remained consistent. Many users praised these bottles for their portability and for being the same trusted formula given in hospitals. The only real downside is the cost-per-ounce compared to powder, but for the sheer convenience and peace of mind it offers, we believe it’s a worthy investment, especially for the diaper bag or bedside table.

#4 Enfamil NeuroPro Infant Formula Ready-to-Feed – Ideal for: Brain Development with Maximum Convenience

Similar to the Similac ready-to-feed option, the Enfamil NeuroPro Infant Formula Ready-to-Feed bottles offer incredible convenience paired with top-tier nutrition. We loved keeping these on hand for trips out of the house. The peace of mind knowing you have a perfectly prepared, sterile bottle ready at a moment’s notice is invaluable. This formula brings all the benefits of the NeuroPro line, including brain-building MFGM and DHA, into a portable format. We found the standard bottle neck to be a thoughtful touch, making it compatible with many popular nipple brands, which isn’t always the case with ready-to-feed options. The formula itself is smooth and was readily accepted by our little testers. For babies who are already thriving on Enfamil NeuroPro powder, this is the perfect companion for travel or emergencies. However, we did notice, as did several users, that quality control can sometimes be an issue, with some reports of expired products or damaged packaging upon arrival. When the product arrives in good condition, it’s an excellent choice for busy parents who don’t want to compromise on cognitive and immune support while on the move.

#5 Enfamil Optimum (Enspire) Baby Formula Refill – Perfect for: Mimicking the Qualities of Breast Milk

The Enfamil Optimum (Enspire) Baby Formula Refill is Enfamil’s premium offering, designed to be their closest formula to breast milk, and our experience with it was impressive. This is the formula we recommend for parents who are supplementing or transitioning from breastfeeding and are concerned about digestive comfort. Its unique composition includes lactoferrin, a key protein also found in colostrum that supports the immune system, and a dual HMO blend (2′-FL & LnNT) that helps build a healthy gut. We found this combination to be exceptionally gentle. Babies we tested it with experienced soft, breast-milk-like stools, making it a fantastic choice for preventing constipation. One user review perfectly captured this, stating, “My baby has breast milk like poop with this formula.” The taste seems to be very palatable, as babies took to it without hesitation. While it is one of the more expensive formulas on the market, its premium ingredients and noticeable gentleness on the digestive system justify the cost for many parents seeking the absolute best alternative to breast milk.

#6 Similac 360 Total Care Sensitive Infant Formula Ready to Feed – Suits: Lactose-Sensitive Babies on the Go

For babies who struggle with fussiness and gas due to lactose sensitivity, the Similac 360 Total Care Sensitive Infant Formula Ready to Feed is a true game-changer. We’ve seen firsthand how this formula can transform a constantly irritable baby into a calm and happy one. Its primary benefit comes from being formulated for lactose sensitivity, which can often be a hidden cause of digestive distress, including constipation. The ready-to-feed format is a huge bonus, especially for tired parents. During our trials, we found it took about 48 hours for a baby to fully adjust, after which there was a significant reduction in gas and discomfort. This experience was mirrored by users, one of whom noted, “I tried this one and it took 48 hrs for her to get adjusted and now she is doing well on it. She sleeps longer too.” Like other Similac 360 formulas, it contains the 5 HMO prebiotic blend for robust immune and digestive support. The 8-ounce bottles are great for older babies, but can lead to waste for younger infants who drink less per feeding, as the remainder must be refrigerated and used quickly.

#7 Similac Alimentum Hypoallergenic Infant Formula 8-fl-oz Bottle, Pack of 24 – Ideal for: Severe Food Allergies and Colic

When standard and sensitive formulas aren’t enough, Similac Alimentum Hypoallergenic Infant Formula 8-fl-oz Bottle, Pack of 24 steps in as a critical solution. This formula is specifically designed for infants with severe food allergies, particularly a cow’s milk protein allergy, which can manifest as colic, eczema, and severe constipation. The protein in Alimentum is extensively hydrolyzed, meaning it’s broken down into tiny pieces that the baby’s immune system is unlikely to react to. In our experience with highly sensitive infants, the results can be dramatic and fast, often showing a reduction in colic symptoms within 24 hours. Users have referred to it as “liquid gold,” and for good reason—it can bring immense relief to babies who have been in constant discomfort. The inclusion of 2′-FL HMO provides valuable immune support, something often needed in babies with allergies. The ready-to-feed format is convenient, but the primary drawback is its high cost. Furthermore, a consistent and frustrating issue noted by many users, which we also find concerning, is the frequency of dented and damaged cans upon delivery. For a premium, medically necessary product, this is a significant issue.

#8 Similac NeoSure Premature Infant Formula Powder 4-Pack – Perfect for: Post-Discharge Nutrition for Preemies

Premature babies have unique nutritional needs, and the Similac NeoSure Premature Infant Formula Powder 4-Pack is expertly crafted to meet them. This isn’t a standard formula; it’s an enriched-nutrition powerhouse designed to promote catch-up growth in babies born early. It contains increased levels of protein, vitamins, minerals, calcium, and phosphorus to support the rapid development of bones and tissues. We’ve worked with many families whose preemies have thrived on NeoSure, showing excellent gains in weight, length, and head circumference as recommended by neonatologists. It also includes DHA and lutein for brain and eye development, which is critical for these little ones. While incredibly beneficial for growth, this calorie-dense formula can sometimes be harder on a preemie’s delicate digestive system, and constipation can be a side effect. It’s crucial to use this formula under a pediatrician’s guidance. A significant number of users have reported severe issues with the packaging, including dented, open, and unusable cans. This is a recurring problem that undermines an otherwise excellent and vital product.

#9 Good Start Soothe Pro Probiotic Infant Formula – Suits: Colicky Babies with Spit-Up and Gas

The Good Start Soothe Pro Probiotic Infant Formula is another fantastic option for tackling general digestive discomfort, including constipation. Its standout ingredient is the probiotic L. reuteri, which has been clinically shown to reduce crying time in colicky babies. We were impressed by how quickly this formula seemed to calm fussy infants. The proteins are 100% whey and are partially hydrolyzed, making them gentle and easy to digest, which helps prevent the hard stools associated with some standard formulas. In our testing, we found it significantly reduced spit-up and gas. As one happy user stated, it led to a “total change. Went from crying 24/7 to happy and smiling.” The formula also contains HMOs and DHA for immune and brain support. A common complaint we found, which is more of an annoyance than a performance issue, relates to the redesigned container. Many users find the new, wider scoop difficult to use with standard-sized bottles, often leading to spills. Despite this design flaw, the formula itself is highly effective for soothing sensitive tummies.

#10 Good Start Dr. Brown’s Gentle Pro Sensitive Tummies Formula – Ideal for: Promoting Softer, Regular Bowel Movements

When the primary concern is constipation and hard stools, the Good Start Dr. Brown’s Gentle Pro Sensitive Tummies Formula is an excellent choice. Modeled after the gentleness of breast milk, its key benefit is promoting softer poops. It achieves this through a combination of comfort proteins (hydrolyzed whey) and the probiotic B. lactis. During our evaluation, we found this formula to be one of the best for ensuring regularity. One user’s review perfectly summed up our findings: “I love this stuff because it keeps them regular like milk straight from Mama’s tap.” The formula has a thicker consistency, which can also be beneficial for babies with mild reflux. Babies transitioning from breast milk often take to this formula very well, as it is exceptionally gentle on the digestive system and does not cause the constipation that can occur when switching to formula. Like its Soothe Pro counterpart, it contains HMOs and DHA for complete nutrition. While it is highly effective, we must note a serious safety concern raised by a user who found a piece of blue plastic in a prepared bottle, possibly from the scoop packaging, highlighting the need for vigilance during preparation.

The Ultimate Buyer’s Guide: How to Choose The Right Product for You

Key Factors to Consider

Choosing a formula can feel overwhelming. Here are the key factors we focus on when evaluating formulas for constipation:

• Protein Type: The protein in cow’s milk formula is the most common culprit for digestive issues. Standard formulas use intact proteins. For sensitive babies, look for formulas with “partially hydrolyzed” or “extensively hydrolyzed” proteins. These proteins are pre-broken down into smaller pieces, making them much easier to digest and less likely to cause constipation.
• Prebiotics and Probiotics: These are your best friends in the fight against constipation. Prebiotics (like GOS, PDX, and HMOs) are fibers that feed the good bacteria in your baby’s gut. Probiotics (like L. reuteri and B. lactis) are the good bacteria themselves. Both work to create a healthy gut environment that promotes softer, more regular stools.
• Lactose Content: While true lactose intolerance is rare in infants, some babies have a sensitivity to it that can cause gas, bloating, and sometimes constipation. A “Sensitive” or “Low-Lactose” formula may provide relief.
• Format: Powder vs. Ready-to-Feed: Powdered formula is the most cost-effective option for daily use. Ready-to-feed liquid formula is sterile, perfectly mixed, and incredibly convenient for travel or nighttime, but it comes at a premium price.

Understanding Prebiotics in Baby Formula

You’ll see terms like HMO, GOS, and PDX on formula labels. What do they mean? These are all types of prebiotics, which are non-digestible carbohydrates that act as food for beneficial gut bacteria (probiotics). Think of them as fertilizer for the healthy garden in your baby’s intestines. Breast milk is naturally rich in a type of prebiotic called Human Milk Oligosaccharides (HMOs). Modern formulas now include HMOs and other prebiotics to mimic this benefit. By promoting a healthy gut microbiome, these ingredients help soften stool consistency and improve digestive regularity, making them a crucial component in any formula aimed at preventing constipation.

Common Mistakes to Avoid

Navigating formula choices can be tricky. Here are a few common pitfalls we’ve seen parents make:

• Switching Too Quickly: A baby’s digestive system needs time to adapt to a new formula. Don’t jump from one brand to another every few days. Give a new formula at least one to two weeks to see if it’s working before making another change.
• Ignoring Pediatrician Advice: Always consult your pediatrician before switching formulas, especially if your baby has severe symptoms like colic, reflux, or potential allergies. They can help rule out underlying medical issues and recommend specialized formulas like hypoallergenic options.
• Incorrect Mixing: Adding too much powder or not enough water can concentrate the formula, leading to dehydration and worsening constipation. Always follow the package instructions precisely.

Frequently Asked Questions

Can baby formula cause constipation?

Yes, absolutely. A baby’s digestive system is still maturing, and the complex proteins in some cow’s milk-based formulas can be difficult for them to break down completely. This can lead to harder, less frequent stools compared to breastfed babies, whose stools are typically very soft and frequent. The composition of formula is simply different from breast milk, and this change can temporarily back things up.

How can I tell if my baby is constipated from their formula?

It’s less about the frequency and more about the consistency and effort. Look for stools that are hard, dry, and pebble-like. Other signs include your baby straining excessively (turning red, grunting, and crying) for more than 10 minutes without passing a stool, a firm belly, and increased fussiness or refusal to eat. A formula-fed baby may go a day or two without a bowel movement, which can be normal as long as the stool is soft when it passes.

Does the iron in baby formula cause constipation?

This is a common myth. While high doses of iron supplements can cause constipation in adults, the amount of iron used to fortify infant formula is not believed to cause constipation. Iron is an essential nutrient for a baby’s growth and prevention of anemia. Do not switch to a low-iron formula without your pediatrician’s recommendation, as this can be harmful to your baby’s development.

How quickly should a new formula help relieve my baby’s constipation?

You should give a new formula at least one to two weeks to see a noticeable improvement. The digestive system needs time to adjust. Some formulas designed for gentleness, like those with hydrolyzed proteins, may show results in just a few days, but it’s important to be patient. If you don’t see any positive changes after two weeks, consult your pediatrician again.

Are formulas with prebiotics or probiotics better for preventing constipation?

Yes, they are generally very effective. Prebiotics (like HMOs and GOS) act as food for good gut bacteria, while probiotics are the good bacteria themselves. Both help to create a healthier digestive environment, which almost always leads to softer, easier-to-pass stools. We highly recommend looking for a formula that contains one or both of these ingredients if constipation is a concern.

Should I consider a soy or goat milk formula for a constipated baby?

You should only switch to a soy or goat milk formula under the direction of your pediatrician. While some parents find success, these are not typically the first line of defense. Constipation is often related to the protein structure, not the milk source itself. For babies with a confirmed cow’s milk protein allergy, a hypoallergenic formula is usually a better choice than soy, as many babies allergic to cow’s milk are also allergic to soy.

Is it safe to give my baby a little water or juice to help with constipation?

You should never give a baby under six months old extra water or juice unless specifically instructed by your pediatrician. Babies get all the hydration they need from formula or breast milk. Giving them extra water can interfere with their nutrient absorption and, in rare cases, can be dangerous. For older babies (over 4-6 months, as advised by your doctor), a small amount of prune or pear juice (1-2 ounces) might be recommended, but this should always be done under medical guidance.

Conclusion: Our Final Recommendation

After extensive testing and careful consideration of ingredients, effectiveness, and user feedback, we confidently stand by our top pick. For parents seeking a reliable, fast-acting solution for formula-related constipation, gas, and fussiness, the Enfamil NeuroPro Gentlease Fussiness Relief Baby Formula is the clear winner. Its success lies in its smart, gentle design: the partially hydrolyzed proteins are easy for sensitive systems to process, while the PDX & GOS prebiotic blend actively works to soften stools and promote gut health. This dual-action approach provides comprehensive relief, allowing your baby to be more comfortable and happy, which is the ultimate goal for any parent.