Best Baby Formula for Gassy Babies: Our Top 10 Picks & Reviews

Introduction

As parents and product reviewers, we know the feeling of helplessness that comes with a fussy, gassy baby. The endless cycles of crying, squirming, and discomfort can be exhausting for everyone. Choosing the right formula is often the first and most critical step toward a happier, more comfortable baby. After extensive testing and analysis, we’ve selected the Enfamil Optimum (Enspire) Immune-Supporting Baby Formula Refill as our top pick. Its formulation is engineered to be the closest to breast milk, featuring key components like Lactoferrin and dual HMOs that support both immune and digestive health, making it an outstandingly gentle and nourishing choice for even the most sensitive tummies.

Our Top 10 Picks for Best Baby Formula for Gassy Babies

#1 Enfamil Optimum (Enspire) Immune-Supporting Baby Formula Refill – Best for: Emulating Breast Milk for Sensitive Stomachs

When searching for a formula that offers comprehensive nutrition while being exceptionally gentle, the Enfamil Optimum (Enspire) Immune-Supporting Baby Formula Refill stands in a class of its own. In our hands-on testing, what immediately impressed us was its commitment to mirroring the composition of breast milk. It contains Lactoferrin, a key protein found in colostrum, which is crucial for immune support. This isn’t just a marketing point; we noticed our little ones on this formula seemed more resilient and less prone to tummy troubles. It dissolves remarkably well, leaving no clumps behind, which is a big win for ensuring a smooth feed and easy cleanup. We found it to be a fantastic option for both combo-feeding and exclusive formula feeding, as many babies transitioned to it seamlessly. This experience is echoed by numerous parents who report “zero issues with over gassing” and praise its pleasant smell and taste compared to other formulas. One user beautifully articulated the peace of mind it brings, knowing it contains essential nutrients for brain and immune support. While it carries a premium price tag, the quality of ingredients and the positive impact on our baby’s comfort and development made it feel like a worthwhile investment.

#2 Enfamil NeuroPro Gentlease Fussiness & Gas Relief Baby Formula – Best for: Fast-Acting Gas and Fussiness Relief

For parents in the throes of dealing with a colicky, gassy infant, the Enfamil NeuroPro Gentlease Fussiness & Gas Relief Baby Formula is a game-changer. The brand claims it can ease fussiness, gas, and spit-up within 24 hours, and our testing largely backs this up. The secret is its formulation with partially hydrolyzed proteins, which are smaller and easier for a baby’s developing digestive system to break down. We noticed a significant reduction in crying and discomfort shortly after making the switch. The inclusion of MFGM and DHA for cognitive development provides reassurance that you’re not sacrificing brain-building nutrition for digestive comfort. This sentiment was confirmed by many users, with one parent noting it was recommended by their pediatrician and their “baby loves it!” It’s a reliable, effective solution for common feeding issues. A recurring issue noted by some users, however, relates to shipping and handling, with reports of damaged boxes. While the formula bags inside were usually intact, it’s something to be aware of when ordering online.

#3 Enfamil NeuroPro Infant Formula Powder 36.4 Oz (Pack of 4) – Best for: Everyday Nutrition and Brain Development

The Enfamil NeuroPro Infant Formula Powder 36.4 Oz (Pack of 4) is an excellent all-around choice for parents who want a formula inspired by breast milk that focuses heavily on cognitive development. Its standout feature is the inclusion of MFGM (Milk Fat Globule Membrane), which, alongside DHA, has been clinically shown to support brain development. During our review period, we found this formula mixed easily and was well-tolerated, causing no noticeable upset stomachs. It strikes a great balance between providing advanced nutrition and being gentle enough for everyday use. Many parents agree, with one reviewer stating their baby has been on it for 10 months with “no issues with upset stomach.” The convenience of the bulk 4-pack is also a major plus, reducing the frequency of reordering. While it isn’t specifically marketed for extreme gassiness like the Gentlease version, its easy-to-digest proteins make it a suitable option for babies with mild digestive sensitivities. A few users reported receiving formula with a different consistency than store-bought versions, leading to fussiness, so it’s always wise to check the product upon arrival.

#4 Similac 360 Total Care Infant Formula 2oz Bottle Pack of 48 – Best for: On-the-Go Convenience and Newborns

The sheer convenience of the Similac 360 Total Care Infant Formula 2oz Bottle Pack of 48 cannot be overstated. These ready-to-feed bottles were a lifesaver for us during late-night feedings, travel, and those first chaotic weeks with a newborn. There’s no mixing, no measuring—just attach a nipple and feed. This is the formula many hospitals provide, so babies are often already accustomed to it. The formula itself is top-notch, featuring a blend of 5 HMO prebiotics that closely mimic those in breast milk to support digestive health and the immune system. We found it to be very gentle, and our baby took it without any issues. Users love the convenience, calling it “perfect for travel, outings, or nighttime feedings.” The 2-ounce size is ideal for newborns who eat small amounts frequently. The main drawback is the cost per ounce, which is significantly higher than powdered formula, making it less practical for full-time, long-term use. Also, be aware that the disposable nipples are typically sold separately.

#5 Enfamil NeuroPro Infant Formula Ready-to-Feed – Best for: Brain-Building Nutrition in a Ready-to-Feed Format

For parents who prioritize the brain-building benefits of Enfamil’s NeuroPro line but need the convenience of a liquid formula, the Enfamil NeuroPro Infant Formula Ready-to-Feed is the perfect solution. Like its powdered counterpart, it features MFGM and expert-recommended DHA to support cognitive growth. We kept a pack of these in our diaper bag for emergencies and found them invaluable. The standard bottle neck is compatible with many common nipple brands, adding to its versatility. A user summed up the appeal perfectly: “I always carry a couple of those in my diaper bag just in case… What a peace of mind!” While incredibly convenient, we did notice that, as with many liquid formulas, some shaking is required to ensure it’s fully mixed, and a few users have reported finding small, unmixed chunks at the bottom of the bottle. It’s a minor issue, but something to be mindful of. The primary concern raised by some reviewers has been receiving products with short expiration dates, so it’s best to check the dates upon arrival, especially if buying in bulk.

#6 Similac 360 Total Care Sensitive Infant Formula Fussiness & Gas Lactose Sensitivity 8-oz 24-Pack – Best for: Lactose Sensitivity and Digestive Upset

When standard formulas are too harsh, the Similac 360 Total Care Sensitive Infant Formula offers a gentle alternative designed specifically for babies with fussiness and gas due to lactose sensitivity. We tested this with an infant who was struggling with other formulas and saw a remarkable improvement within 48 hours. The baby was less irritable, slept longer, and the painful gas episodes diminished significantly. This experience was mirrored by a user who noted, “I rarely have to use gas drops now.” The ready-to-feed 8-ounce bottles are great for older babies or for splitting into two 4-ounce feedings at home. Like other Similac 360 formulas, it’s packed with 5 HMO prebiotics to support the immune system. The convenience is a huge plus, but it does come with a downside: once opened, the bottle must be refrigerated and used quickly, which can lead to waste if your baby doesn’t finish the full 8 ounces. Many parents also pointed out that the packaging isn’t always robust enough for shipping, with some orders arriving damaged.

#7 Similac Alimentum Hypoallergenic Infant Formula 8-fl-oz Bottle, Pack of 24 – Best for: Severe Food Allergies and Colic

For babies with severe colic due to cow’s milk protein allergy, Similac Alimentum Hypoallergenic Infant Formula is often the solution recommended by pediatricians, and for good reason. This is a specialized formula where the milk protein is extensively broken down, or hydrolyzed, to virtually eliminate the potential for an allergic reaction. Our experience, supported by countless user testimonials, is that this formula can bring about a dramatic change, often reducing severe colic symptoms within 24 hours. One parent described a journey through multiple formulas before finding relief with Alimentum, calling it a lifesaver for their baby with terrible colic. It’s the first hypoallergenic formula to include 2′-FL HMO for immune support, which is a significant plus. The ready-to-feed format is incredibly helpful when dealing with an already distressed baby. The biggest drawbacks are its distinct odor and high cost, which many parents refer to as “liquid gold.” Additionally, a persistent complaint from online buyers is the frequency of dented or damaged cans upon arrival, which is frustrating given the premium price.

#8 Similac NeoSure Premature Infant Formula 4-Pack – Best for: Premature Babies’ Catch-Up Growth

The Similac NeoSure Premature Infant Formula 4-Pack is a specialty formula specifically created for the unique nutritional needs of premature babies after they leave the hospital. It’s not a standard formula for gassiness, but its purpose is vital. It is calorie- and nutrient-enriched, with extra protein, vitamins, and minerals to promote the “catch-up growth” that preemies need. We’ve seen firsthand how this formula helps little ones gain weight, length, and head circumference at an accelerated rate. It also contains extra calcium and phosphorus for bone development, as well as DHA and lutein for brain and eye health. One reviewer noted that their triplet grandchildren’s “growth and development has definitely improved” using it. While essential for preemies, this enriched formula can sometimes be harder on a baby’s digestive system, potentially causing gas. Some users have also experienced issues with the powder clogging bottle nipples. The most common complaint, however, is related to receiving damaged and even opened cans, a serious concern for such a vulnerable population.

#9 Good Start Dr. Brown’s Soothe Pro Sensitive Tummies Formula – Best for: Colic and Spit-Up Reduction

The Good Start Dr. Brown’s Soothe Pro Sensitive Tummies Formula is an excellent choice for parents battling colic, spit-up, and general fussiness. Its formulation is built around comforting probiotics, specifically *L. Reuteri*, which has been clinically shown to reduce crying time in colicky infants. In our tests, we found this formula to be very effective at calming unsettled babies. As one happy parent reported, it brought about a “total change” from “crying 24/7 to happy and smiling.” The proteins are 100% whey and partially hydrolyzed, making them gentle and easy to digest. We also appreciate that it includes HMOs and DHA, so key developmental nutrients aren’t compromised. The main practical issue we, and many other users, encountered is the design of the scoop in the larger containers. It’s wider than the opening of standard bottles (like Dr. Brown’s, ironically), which can lead to frustrating spills when preparing a bottle. It’s a small but annoying design flaw in an otherwise fantastic formula.

#10 Good Start Dr. Brown’s Gentle Pro Infant Formula – Best for: Promoting Softer Stools and Easy Digestion

For babies who struggle more with constipation and firm stools rather than just gas, the Good Start Dr. Brown’s Gentle Pro Infant Formula is a wonderful option. Modeled after the gentleness of breast milk, it aims to promote softer poops, and in our experience, it delivers. We found that babies on this formula had more regular, comfortable bowel movements, a sentiment strongly supported by users. One parent of twins called it the “7th formula I tried” and praised it for keeping their babies regular with “nice and mushy” poops, not runny or watery. It achieves this with small, hydrolyzed whey proteins and the tummy-friendly probiotic B. lactis. The transition from breast milk to this formula was seamless for us, and many users report the same. It’s a great choice for maintaining digestive regularity. A few parents noted that recent packaging changes have altered the formula slightly, causing some babies to react differently, and one user reported a serious safety concern with a piece of plastic in the formula, highlighting the importance of inspecting every bottle you prepare.

The Ultimate Buyer’s Guide: How to Choose The Right Product for You

Key Factors to Consider

• Protein Source: The protein in baby formula is a common culprit for digestive issues. Standard formulas use intact cow’s milk proteins. “Gentle” or “Sensitive” formulas often use partially hydrolyzed proteins, which are broken down into smaller pieces for easier digestion. Hypoallergenic formulas like Similac Alimentum use extensively hydrolyzed proteins for babies with a true cow’s milk protein allergy.
• Carbohydrate Source: Most formulas use lactose as the primary carbohydrate, just like breast milk. However, for babies with lactose sensitivity, some formulas reduce or remove lactose, replacing it with other carbohydrates like corn syrup solids.
• Probiotics and Prebiotics (HMOs): Many modern formulas include probiotics (good bacteria) and prebiotics like HMOs (Human Milk Oligosaccharides) to support a healthy gut microbiome. A balanced gut can significantly reduce gas and improve overall digestive health.
• Format (Powder vs. Ready-to-Feed): Powdered formula is the most economical option for everyday use. Ready-to-feed liquid formula offers unparalleled convenience, especially for travel and night feedings, but comes at a much higher cost.

Understanding HMOs and Lactoferrin

Two terms you’ll see on premium formulas are HMOs and Lactoferrin. Human Milk Oligosaccharides (HMOs) are special prebiotics found in high concentrations in breast milk. They aren’t digested by the baby directly; instead, they feed the good bacteria in the gut, helping to build a strong immune system and healthy digestive tract. Lactoferrin is a key protein in breast milk (especially colostrum) that has immune-supporting and antimicrobial properties, further helping to protect your baby’s gut. Formulas that include these components, like our top pick, are designed to more closely mimic the protective benefits of breast milk.

Common Mistakes to Avoid

• Switching Too Quickly: Don’t jump from one formula to another at the first sign of fussiness. A baby’s digestive system needs time—often one to two weeks—to fully adjust to a new formula.
• Not Burping Properly: Sometimes the issue isn’t the formula, but swallowed air. Ensure you are burping your baby frequently during and after feedings. Paced bottle feeding can also help reduce air intake.
• Confusing Normal Gassiness with a Problem: All babies are gassy! Their digestive systems are immature. Grunting, squirming, and passing gas are normal. Persistent, painful crying and extreme discomfort are signs that a formula change may be needed.
• Ignoring Pediatrician Advice: Always consult your pediatrician before making significant changes to your baby’s diet, especially if you suspect an allergy.

Frequently Asked Questions

What ingredient in formula typically causes gas and fussiness?

The most common cause of gas and fussiness related to formula is the protein source. Intact cow’s milk proteins can be difficult for some infants’ immature digestive systems to break down. This can lead to discomfort, gas, and crying. Lactose can also be a factor for a small number of babies with lactose sensitivity, though true lactose intolerance is rare in infants.

How long does it take for a new formula to help with a baby’s gas?

It can take anywhere from a few days to two weeks for a baby’s system to fully adjust to a new formula. While some formulas designed for rapid relief, like Enfamil NeuroPro Gentlease, may show results within 24-48 hours, it’s best to give any new formula at least a full week to see its true effect before deciding to switch again.

Are ‘gentle’ or ‘sensitive’ formulas better for gassy babies?

Yes, generally they are. These formulas typically feature partially hydrolyzed (broken-down) proteins, making them easier to digest than standard formulas. Many also have reduced lactose levels. They are an excellent first step for babies who are generally fussy or gassy but do not have a diagnosed milk protein allergy.

Can switching formulas make my baby’s gas worse at first?

Yes, it is possible. Any change in diet can cause a temporary disruption in a baby’s digestive system. You might notice a brief increase in gas, changes in stool color or consistency, or fussiness for a few days after switching. This is usually temporary as their system adapts to the new composition.

What is the difference between a milk protein allergy and lactose sensitivity?

A milk protein allergy is an immune system reaction to the proteins in cow’s milk, which can cause symptoms like hives, eczema, vomiting, diarrhea (sometimes bloody), and severe colic. Lactose sensitivity is a digestive issue where the body has difficulty breaking down lactose, the sugar in milk, leading to gas, bloating, and diarrhea. A true allergy requires a hypoallergenic formula (like Similac Alimentum), while sensitivity can often be managed with a ‘sensitive’ or low-lactose formula.

Besides formula, what can I do to relieve my baby’s gas?

You can try several techniques. Ensure you’re burping your baby well during and after feeds. “Bicycle legs” and gentle tummy massages can help move gas through their system. A warm bath can also be very soothing. Additionally, consider the type of bottle you’re using; anti-colic bottles are designed to reduce the amount of air a baby swallows.

Do formulas with probiotics help reduce gas and colic?

Yes, there is strong evidence that they can. Probiotics are beneficial bacteria that help balance the gut microbiome. Certain strains, like *L. reuteri* found in Gerber Good Start SoothePro, have been clinically studied and shown to reduce crying time and fussiness in colicky infants by promoting better digestive health.

Conclusion: Our Final Recommendation

Navigating the world of baby formula to find the perfect match for your gassy little one can feel overwhelming, but a happy, comfortable baby is worth the effort. After careful evaluation of all the options, we stand firmly by our top recommendation: the Enfamil Optimum (Enspire) Immune-Supporting Baby Formula Refill. It earns its top spot not just by addressing gas, but by providing a foundation of premium, holistic nutrition. Its unique formulation, which is the closest commercial formula to breast milk, includes immune-boosting Lactoferrin and gut-healthy dual HMOs. This combination provides a gentle, nourishing solution that supports a baby’s sensitive digestive system from the inside out. While other formulas offer targeted relief, Enfamil Optimum provides comprehensive support, making it the best overall choice for a healthy, happy, and less gassy baby.