Best Baby Formula: Our Top 10 Picks & Reviews

Introduction

Choosing the right baby formula is one of the most important decisions a new parent can make. It’s a journey to find the perfect balance of nutrition, digestibility, and comfort for your little one. After countless hours of testing, mixing, and late-night feedings, we’ve navigated the vast landscape of infant nutrition to bring you the best options available. Our comprehensive review process led us to a clear winner for its all-around excellence: the Enfamil NeuroPro Gentlease Baby Formula for Fussiness & Gas. This formula stands out for its clinically proven ability to quickly reduce common feeding issues like gas and fussiness, thanks to its gentle, partially hydrolyzed proteins and brain-nourishing ingredients.

Our Top 10 Picks for Best Baby Formula

#1 Enfamil NeuroPro Gentlease Baby Formula for Fussiness & Gas – Ideal for: Babies with Sensitive Tummies

When you have a fussy, gassy baby, every minute feels like an hour. That’s where the Enfamil NeuroPro Gentlease Baby Formula for Fussiness & Gas truly shines, earning its spot as our top pick. During our evaluation, we were immensely impressed by its fast-acting formula. It’s clinically shown to ease fussiness, gas, and spit-up within 24 hours, and in our experience, it lives up to that promise. The secret lies in its partially hydrolyzed proteins, which are smaller and easier for a baby’s developing digestive system to break down. We found it mixed smoothly without excessive clumping, creating a consistent bottle every time. Beyond digestive comfort, this formula is packed with brain-building nutrients like DHA, Choline, and MFGM—a component found in breast milk that supports cognitive development. Our pediatrician-recommended choice was a game-changer for creating happier feeding times. This positive experience was echoed by countless users who praised its gentle effect on their baby’s belly. The value offered in the large 35.2 oz box also means fewer trips to the store, which is always a bonus for busy parents.

#2 Enfamil NeuroPro Infant Formula Powder 36.4 Oz (Pack of 4) – Perfect for: Bulk Buying and Long-Term Development

For parents who like to stock up and save, the Enfamil NeuroPro Infant Formula Powder 36.4 Oz (Pack of 4) is an excellent choice. This is the standard, non-gentle version of our top pick, designed for babies without significant digestive sensitivities. What we admire most is its focus on long-term cognitive benefits. The inclusion of MFGM components has been clinically shown to support development through age five, giving parents peace of mind that they’re providing a strong nutritional foundation. In our testing, the powder was easy to prepare and well-tolerated by babies accustomed to standard formulas. Many users confirmed our findings, noting that their babies thrived on it for months with no issues. The convenience and cost-effectiveness of the four-pack are significant advantages, ensuring you’re less likely to run out at an inconvenient time. It’s a reliable, high-quality formula that delivers complete nutrition and supports both brain and immune health with its exclusive HuMO6 blend.

#3 Similac 360 Total Care Infant Formula – Suits: Parents Needing On-the-Go Convenience

The Similac 360 Total Care Infant Formula in its ready-to-feed format is an absolute lifesaver for busy parents. We found these 2-fluid-ounce bottles indispensable for travel, late-night feedings, and any situation where mixing powder is impractical. There’s no measuring, no mixing, and no mess—just open and serve. This formula boasts an exclusive blend of 5 HMO prebiotics, which are structurally identical to those in breast milk and are designed to provide comprehensive support for immune health, brain development, and digestion. Our little testers accepted it readily, and we appreciated its long shelf life (until opened). Many users highlighted this convenience as a primary reason for their purchase, keeping a stash at home for outings or emergencies. While it’s more expensive per ounce than its powdered counterparts, the trade-off for convenience is often worth it. It’s a fantastic supplement to your primary formula or a great standalone option for parents who prioritize ease of use above all else.

#4 Enfamil NeuroPro Infant Formula – Best for: Convenient Brain-Boosting Nutrition

Similar to the Similac option, the ready-to-feed Enfamil NeuroPro Infant Formula offers unparalleled convenience with the added benefit of Enfamil’s signature brain-building formula. These 2-fluid-ounce bottles contain the same MFGM components and expert-recommended DHA as the powdered version, ensuring your baby gets top-tier nutrition even when you’re on the move. We particularly liked that the bottle necks are a standard size, making them compatible with many common nipple brands—a small detail that makes a big difference. Keeping a few of these in the diaper bag brought us significant peace of mind during long outings. Users often praise these bottles as a perfect supplement for breastfeeding mothers or for simplifying travel. However, a recurring concern among reviewers that we also noted is the potential for quality control issues. Several users reported receiving expired products or finding sediment at the bottom of the bottles, so it’s crucial to inspect each one carefully before feeding.

#5 Enfamil Enspire Immune-Supporting Baby Formula Powder Refill – Ideal for: Parents Seeking a Formula Closest to Breast Milk

For parents who want to get as close to breast milk as possible, the Enfamil Enspire Immune-Supporting Baby Formula Powder Refill (now named Enfamil Optimum) is our top recommendation. This premium formula stands out by including key components found in breast milk, such as Lactoferrin, a protein crucial for immune support, and a dual blend of HMOs. In our evaluation, we found it dissolved quickly and had a pleasant, less “formula-like” smell compared to other brands. Babies transitioned to it smoothly, and many parents who combo-feed reported great success. One user beautifully described how this formula gave them peace of mind when struggling with low breast milk production, knowing their baby was still receiving high-quality, immune-supporting nutrition. The powder refill bags are designed to be used with a reusable tub, which helps reduce plastic waste. While it carries a premium price tag, the advanced formulation and high-quality ingredients make it a worthwhile investment for many families.

#6 Similac 360 Total Care Sensitive Infant Formula – Perfect for: Easing Fussiness from Lactose Sensitivity

When fussiness and gas are specifically linked to lactose sensitivity, the Similac 360 Total Care Sensitive Infant Formula is an excellent solution. This ready-to-feed formula is designed to be gentle on tiny tummies while still providing the comprehensive nutrition of the 360 Total Care line, including the 5-HMO prebiotic blend. We saw a noticeable improvement in comfort with babies prone to gas pains after switching to this formula. As one parent noted, it took about 48 hours for their newborn to adjust, after which she became less irritable and slept longer. The 8-fluid-ounce ready-to-feed bottles are incredibly convenient for at-home use, though they can be a bit wasteful if your baby doesn’t finish the full amount in one sitting, as the remainder must be refrigerated and used quickly. It’s a fantastic choice for parents who suspect lactose sensitivity and prefer the ease of a liquid formula. We found it to be a reliable problem-solver for common feeding discomforts.

#7 Similac Alimentum Hypoallergenic Infant Formula Ready-to-Feed 8-oz Bottle – Suits: Babies with Cow’s Milk Protein Allergies and Colic

For babies with significant food allergies or severe colic due to protein sensitivity, Similac Alimentum Hypoallergenic Infant Formula Ready-to-Feed 8-oz Bottle can be a true lifesaver. This formula is hypoallergenic, meaning the milk protein is extensively broken down into tiny pieces to prevent allergic reactions. Its claim to start reducing colic symptoms within 24 hours is bold, but in many cases, we found it to be accurate. We’ve seen this formula transform inconsolable babies into calm, comfortable ones. One parent shared a story of their preemie who struggled with colic on multiple other formulas before finding relief with Alimentum. It’s also the first hypoallergenic formula to include 2′-FL HMO for immune support. The primary drawback is its high cost, often referred to as “liquid gold” by parents. Another significant issue, frequently cited by users, is the prevalence of dented cans upon delivery. Despite these challenges, for babies who truly need it, its effectiveness is undeniable and often worth every penny.

#8 Similac NeoSure Premature Infant Formula 4-Pack – Best for: Premature Babies Needing Catch-Up Growth

Premature babies have unique nutritional needs, and the Similac NeoSure Premature Infant Formula 4-Pack is specifically designed to meet them. Recommended by neonatologists and used in hospitals, this formula is enriched with increased protein, vitamins, and minerals to promote excellent catch-up growth after hospital discharge. It supports better gains in weight, length, and head circumference compared to standard term formulas. We’ve seen firsthand how this formula helps preemies thrive, providing the extra calories and nutrients like calcium and phosphorus needed for developing bones. While its nutritional benefits are clear and praised by parents of multiples and preemies alike, the formula itself can be tricky. We and other users have noted that it can sometimes clog bottle nipples if not shaken vigorously. The most significant and persistent complaint, however, revolves around shipping and packaging. Many users receive packages with dented or even broken cans, which is a major concern for such a vital product. When you can get it intact, it’s an excellent choice for helping your little one catch up.

#9 Good Start Dr. Brown’s Soothe Pro Sensitive Tummy Formula – Ideal for: Colicky Babies and Reducing Crying Time

The Good Start Dr. Brown’s Soothe Pro Sensitive Tummy Formula is a fantastic option for parents battling colic. Its standout ingredient is the comforting probiotic *L. reuteri*, which has been clinically shown to reduce crying time by 50% in colicky infants. We were impressed by how quickly it seemed to soothe fussy babies, a sentiment shared by many users who called it a “total change” that turned their crying baby into a happy one. The formula is made with 100% high-quality whey protein that has been hydrolyzed, or broken down, into smaller pieces, making it exceptionally easy to digest and helping to reduce spit-up. We found it to be a well-tolerated and affordable alternative to some of the more expensive gentle formulas. One common frustration we encountered, which was a frequent point in user reviews, is the design of the scooper. In the larger containers, the scoop is wider than the opening of standard bottles, leading to spills and wasted formula. Despite this design flaw, the formula’s effectiveness in comforting sensitive tummies makes it a strong contender.

#10 Good Start Gentle Pro Sensitive Tummies Formula – Perfect for: Promoting Softer, More Regular Stools

If your baby struggles with constipation or hard stools, the Good Start Gentle Pro Sensitive Tummies Formula is designed to help. Modeled after the gentleness of breast milk, this formula is crafted to be easy on the digestive system and promote softer poops. It uses 100% hydrolyzed whey protein and includes the tummy-friendly probiotic *B. lactis*. In our experience, this formula is excellent for babies who need a little extra help staying regular without needing a medicated solution. One parent noted that after trying seven different formulas, this was the only one that helped their twins avoid grunting and struggling with bowel movements, producing stools that were “nice and mushy.” It’s also a great option for breastfed babies transitioning to formula, as many users reported a seamless switch. While the formula itself is highly praised, we must note a serious safety concern raised by one user who found a piece of blue plastic in a prepared bottle, potentially from the scooper. This highlights the importance of always inspecting formula and packaging carefully.

The Ultimate Buyer’s Guide: How to Choose The Right Product for You

Key Factors to Consider

• Protein Source: Most formulas are based on cow’s milk, but the proteins can be intact or hydrolyzed (partially broken down). Hydrolyzed proteins, found in “Gentle” or “Sensitive” formulas, are easier to digest and ideal for babies with gas or fussiness. For severe allergies, hypoallergenic formulas with extensively broken-down proteins are necessary.
• Format (Powder vs. Ready-to-Feed): Powder is the most economical option but requires careful measuring and mixing. Ready-to-feed liquid is incredibly convenient, especially for travel or late nights, but is more expensive and must be refrigerated after opening.
• Key Ingredients: Look for formulas fortified with DHA and ARA, fatty acids crucial for brain and eye development. Many formulas now also include prebiotics or Human Milk Oligosaccharides (HMOs) to support immune health and promote healthy gut bacteria, mimicking a key benefit of breast milk.
• Specialized Needs: Consider if your baby has specific issues. There are formulas for lactose sensitivity, spit-up (often thickened with rice starch), colic, allergies (hypoallergenic), and prematurity (calorie- and nutrient-dense).

Understanding HMOs and Prebiotics

You’ll see “HMO” on many formula labels. HMOs, or Human Milk Oligosaccharides, are special prebiotics found naturally in breast milk. They are not digestible by babies but serve as food for the good bacteria in their gut. A healthy gut microbiome is essential for a strong immune system and proper digestion. Formulas that include HMOs, like Similac 360 Total Care and Enfamil NeuroPro, are designed to more closely mimic the immune-boosting benefits of breast milk. While not a perfect replication, their inclusion is a significant advancement in infant nutrition.

Common Mistakes to Avoid

• Switching Too Quickly: Don’t switch formulas at the first sign of fussiness. It can take a baby’s digestive system up to a week to fully adjust to a new formula. Give it time unless there is a clear allergic reaction.
• Incorrect Mixing: Always follow the package instructions precisely. Adding too much water can dilute essential nutrients, while not adding enough can lead to dehydration and constipation. Always add water to the bottle first, then the powder.
• Ignoring Pediatrician’s Advice: While online reviews and guides like this are helpful, your pediatrician knows your baby’s specific health history. Always consult them before making a switch, especially if you suspect an allergy or medical issue.
• Stockpiling an Untested Formula: Never buy a large quantity of a new formula before you know if your baby will tolerate it. Buy a single can to start.

Frequently Asked Questions

What is the closest formula to breast milk?

Formulas like the Enfamil Enspire Immune-Supporting Baby Formula Powder Refill are designed to be the closest to breast milk. They often contain key components found in breast milk that other formulas may not, such as Lactoferrin (an immune-supporting protein) and a dual blend of HMOs (prebiotics that feed good gut bacteria).

How do I choose the right baby formula for my newborn?

Start with a standard, iron-fortified cow’s milk-based formula unless your pediatrician advises otherwise. Observe your baby for signs of discomfort like excessive gas, fussiness, spit-up, or constipation. If these issues persist, discuss switching to a “gentle” or “sensitive” formula with partially hydrolyzed proteins, like our top pick, Enfamil NeuroPro Gentlease, with your doctor.

Are expensive baby formulas really better than store brands?

Not necessarily. All formulas sold in the US must meet the same FDA nutritional standards. The price difference often comes down to proprietary blends of ingredients like specific probiotics or HMOs, and brand marketing. Store brands can be a safe and affordable option. However, premium brands often lead the way in research and adding beneficial, though non-essential, ingredients like MFGM or Lactoferrin.

What’s the difference between cow’s milk, soy, and goat’s milk formula?

Cow’s milk formula is the most common and is the standard recommendation. Soy formula is an option for rare cases like galactosemia or for families who prefer a vegetarian diet, but it’s not recommended for treating standard milk protein allergies, as many babies allergic to cow’s milk are also allergic to soy. Goat’s milk formula has a slightly different protein structure that some babies may find easier to digest, but it is not a suitable alternative for a diagnosed cow’s milk allergy.

Should I choose an organic or non-GMO baby formula?

This is a personal choice. Organic formulas are made from milk from cows that were not treated with growth hormones or antibiotics and were fed organic feed. Non-GMO formulas ensure that ingredients are not genetically engineered. While these options provide peace of mind for some parents, they are not nutritionally superior to conventional formulas by FDA standards.

What are the key ingredients to look for in a baby formula?

Look for iron (essential for preventing anemia), DHA and ARA (for brain/eye development), and a healthy carbohydrate source like lactose. Increasingly, beneficial additions include prebiotics (GOS, FOS) and HMOs for digestive and immune health, and probiotics (*L. reuteri*, *B. lactis*) for gut comfort.

How long can a baby stay on infant formula before switching?

Babies should stay on infant formula (Stage 1) for their entire first year. Around 12 months of age, you can typically transition them to whole cow’s milk, as recommended by your pediatrician. There is generally no need to switch to “toddler formulas” (Stage 2 or 3) unless medically advised.

Conclusion: Our Final Recommendation

After thorough testing and analysis, our top recommendation remains the Enfamil NeuroPro Gentlease Baby Formula for Fussiness & Gas. It masterfully addresses the most common and stressful feeding challenges—gas, fussiness, and crying—with a gentle, fast-acting formula that parents can trust. Its blend of easy-to-digest proteins provides immediate comfort, while the inclusion of brain-building nutrients like MFGM and DHA offers long-term developmental support. It strikes the perfect balance between solving immediate problems and investing in your baby’s future health, making it the best all-around choice for most families navigating the world of infant formula.